Clinical Leadership

Bai-Lin Wu, PhD

Principal Genomic Scientist/Co-Founder Claritas Genomics

Bai-Lin Wu brings more than 30 years of experience in molecular diagnostics to Claritas Genomics, creating Boston Children’s Molecular Diagnostic lab nearly 20 years ago with himself as the sole staff. Bai-lin and his team designed a 60-mer oligo DNA chip for high resolution genomic DNA copy number variant analysis. The test was used to detect sub-microscopic genomic deletions and duplications associated with developmental delay, intellectual disability, and autism spectrum disorders and was one of first U.S. CLIA certified labs to use this advanced technique. The lab’s work provided the groundwork for the American College of Medical Genetics to issue clinical guidelines for the use of chromosomal microarray analysis in the primary evaluation of developmental delay. The outgrowth of this work allowed development of a rapid and cost-effective assay for copy number variation at 16p11.2 resulting in U.S. patent #8,003,326. Over the last 10 years Bai-lin has trained more than 30 postdoctoral fellows through the Harvard Medical School Genetics Training program, as well as numerous medical students and residents. He also is on the Faculty at Fudan University in Shanghai and is active in building high quality molecular diagnostic and academic programs in China. Bai-lin is credited on more than 70 publications with more than 30 as first author.

Dr. Wu received the Master of Medicine in Medical Genetics at Shanghai Medical University, China before immigrating to the US. He received his PhD in Molecular Genetics from Boston University, and did his clinical genetics fellowship training in the Harvard Genetics Training Program. He is a Diplomate of the American Board of Medical Genetics and Assistant Professor in Pathology at Harvard Medical School.

Yiping Shen, PhD FACMG

Director, Research & Development

Yiping Shen is a ACMG-board certified medical director at Claritas. He has over 20 years’ experience in human genetic research and over 10 years’ experience in clinical molecular testing service. He also directed the R&D activity at the Genetic Diagnostic Laboratory (GDL) at Boston Children’s Hospital and developed and updated many tests including MLPA based targeted copy number tests, microarray based whole genome CNV+SNP test, as well as Sanger and Next Generation Sequencing based tests. He co-directs the R&D at Claritas. He has published numerous articles on the discovery of novel disease genes and contributed to a better understanding of genotype-phenotype correlations that are the basis for clinical interpretation and counseling. His research interests in understanding the genetic causes of pediatric genetic disorders, particularly developmental disorders provide unique value for the genetic diagnostic testing service for pediatric patient population at Claritas.

Dr. Shen is a reviewer for more than ten academic journals and had been invited for many talks nationally and internationally. He also provides training for research and clinical fellows and teaches for the Harvard Genetic Training program from which he was initially trained. He is an assistant professor at the Pathology Department at Harvard Medical School. He is also on the Faculty at Jiaotong University in Shanghai.

Dr. Shen received the Master of Science in Developmental Biology at Wuhan University, China. He received his PhD in Pharmacology from Upstate Medical University, Syracuse, New York. He did his clinical genetics fellowship training in the Harvard Genetics Training Program. He is board-certified in Clinical Molecular Genetics. He is a Diplomate of the American Board of Medical Genetics.

David Miller, MD, PhD

Assistant Director

David Miller is a medical geneticist and Assistant Director of Claritas Genomics, and an Assistant Professor of Pediatrics at Harvard Medical School. Dr. Miller’s experience as a clinician who orders genetic tests and provides results directly to patients, combined with expertise in developing and performing clinical laboratory diagnostic assays, provides him with a unique and valuable perspective. Dr. Miller has broad experience as a lab director within the GDL, overseeing clinical interpretation and reporting of all genetic testing, and quality control of the clinical laboratory. He has published numerous articles on the topic of clinical genetic testing, including diagnostic yield and clinical utility. He received his MD and PhD degrees from Washington University School of Medicine in St. Louis, completed a residency in Pediatrics at Yale-New Haven Hospital, and residency/fellowship in medical genetics and clinical molecular genetics at Harvard Medical School. He is board-certified in Clinical Genetics and Clinical Molecular Genetics.

Mark Kellogg, PhD

Clinical Leader

Dr. Kellogg is currently the Director of Quality Programs and Associate Director of Chemistry, Dept. of Laboratory Medicine at Boston Children’s Hospital, and an Assistant Professor of Pathology at Harvard Medical School, in Boston Massachusetts. His research focuses on adaptation of mass spectrometry to clinical assays and biomarkers of cognitive function. He has over 45 publications.

From January 1999 until August of 2007, Dr. Kellogg was a research biochemist on active duty in the US Army. His first assignment was in the Nutrition Division of the US Army Medical Research Institute of Environmental Medicine, Natick Massachusetts. Here he worked primarily with nutritional modulation of physical and cognitive performance and the clinical chemistry associated with monitoring performance. Through the Army’s Long Term Higher Education and Training program, Dr. Kellogg completed his post-doctoral training in Clinical Chemistry at Boston Children’s Hospital. His final assignment with the Army was at the US Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, where he served as the Field Team Leader for the Institutes Diagnostic Systems Division. In addition he was the assistant director for the National Laboratory at USAMRIID, supporting the nation’s Bioterrorism Laboratory Response Network. Prior to his active duty tour, Dr. Kellogg was an Associate Professor at Ferris State University in Big Rapids Michigan, teaching clinical chemistry, phlebotomy and quality courses in the medical technology and medical laboratory technician programs. He received his doctorate in biology from the University of Notre Dame in 1996 where he studied the adaptation of fish to environments of differing salinity. He holds a Bachelor of Science degree in Medical Technology from Michigan Technological University.

Dr. Kellogg is active in the American Association for Clinical Chemistry (AACC), currently serving as Secretary for the Northeast section, is on the executive board for the Nutrition Division and on the boards of the Commission on Accreditation in Clinical Chemistry and the American Board of Clinical Chemistry.

Julie Rousseau MS, CGC

Director, Clinical Client Services

Julie Rousseau is a certified genetic counselor and Director of Clinical Client Services at Claritas Genomics, where she is involved in new diagnostic test development, clinical interpretation and reporting, provider support and education, and utilization management.

Her position at Claritas is an extension of her responsibilities at Boston Children’s Hospital, where she was a laboratory genetic counselor in the Genetics Diagnostic Laboratory and a core member of the utilization management committee, BEST (Bringing Expertise to Selecting Tests). Prior to transitioning to laboratory genetic counseling, Julie was a clinical genetic counselor with a primary focus in pediatrics at Baystate Medical Center, University of California at Davis Medical Center, and Children’s Hospital of Los Angeles. In all of these positions, she has emphasized the importance of educating providers across all specialties in the fundamentals of genetics and genetic testing in order to enable them to be informed consumers and to provide clear and accurate information to their patients.

Julie earned her BA in Biochemistry from Mount Holyoke College and her MS in Human Genetics from Sarah Lawrence College. She is certified by the American Board of Genetic Counseling.